"We use age-based cut-offs to determine normal levels," says Herati. "Keep in mind that a PSA can be a normal range but exhibit a fast rise when followed year to year. This would be
In the PSA value range of 4 to 10 ng/mL, volume-referenced testing was superior to PSA testing (P = less than .01) and age-specific reference ranges (P less than .001) and equivalent to PSA density. In this range, age-specific reference ranges missed the fewest cancers (6%) but resulted in the fewest biopsies (12%).
An age-wise categorization of normal PSA range is provided below: PSA value: Normal reading as per age: 2.4 ng/mL or less: For men younger than 50 years: 3 ng/mL or below: For men younger than 60 years: 4 ng/mL or below: For men aged between 60 and 69 years: 5 ng/mL or below:
Upper limit of normal (ULN) for prostate-specific antigen was recommended as 4 ng/mL when it was firstly introduced into clinical practice. This cut-off value was based on serum PSA measurements of 860 healthy men. Upper limit of normal of age-adjusted median PSA values for various age groups have been determined as follows: 0.7 ng/mL (40
Prostate-specific antigen (PSA) is a glycoprotein produced by the prostate gland, the lining of the urethra, and the bulbourethral gland. The total PSA range of 4.0 to 10.0 ng/mL has been described as a diagnostic "gray zone," in which the free PSA:total PSA ratio helps to determine the relative risk of prostate cancer (see table
Medically reviewed by Mark Pomerantz, MD. Prostate-specific antigen, or PSA, is a protein naturally produced by the prostate gland in men.Because prostate cancer can increase the level of PSA in the blood, many doctors and professional organizations recommend that men over age 50 receive a PSA test in conjunction with a digital rectal exam to help detect the disease as early as possible.
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